基于“气道神经源性炎症-TRP通路”探讨慢性咳嗽发病机制及中医治疗

咳嗽临床常见，尤其是胸部影像学无明显异常的慢性咳嗽，病因复杂、易误诊误治，逐渐受到重视，国内外相继颁发相关指南，目前认为咳嗽高敏感性是其重要的病理生理机制。中医将慢性咳嗽归于"久咳""久嗽"范畴，在病因病机、治法方药上积累了丰富的临床经验，史利卿教授团队针对该病开展了专项临床及基础研究15年，根据传统中医理论及其突出临床症状提出"风邪伏肺"病机，应用祛风宣肺法治疗效果显著。文章结合西医学相关咳嗽机制研究进展及既往研究结果，初步探讨祛风宣肺法治疗该病的疗效机制，丰富慢性咳嗽风邪伏肺致咳相关学术理论的科学内涵，有利于提高中医药防治慢性咳嗽学术水平。     

物联网技术融入《生物医学传感器》实验教学改革的探索与实践

近年来，物联网技术迅猛发展，为医学教育融入物联网技术、培养医工结合的跨学科人才，开辟了广阔前景。研究者在《生物医学传感器》课程实验教学中融入物联网技术，改革实验教学内容和方法，开发设计出基于物联网技术的生物医学传感器实验教学系统；使学生理解物联网在智能医疗设备方面的系统设计方法，培养学生的动手能力和创新能力；并取得初步教学成效。     

Trends in Physical Fitness Among 12-Year-Old Children in Urban and Rural Areas During the Social Transformation Period in China

Aims

To investigate the 29-year (1985–2014) trends in body dimensions and physical fitness test performances among 12-year-old Chinese children living in urban and rural areas.

临床抗青光眼药物的新进展

青光眼是致盲的主要原因之一，构成视神经的神经节细胞轴突受到多种因素的损伤，其机制尚未完全明了。青光眼最重要的危险因素是眼压升高。由于青光眼的视神经损伤尚不能直接治疗，根据目前提供的唯一已知可治疗的危险因素，可以降低升高的眼压，而眼压与房水流出通道的功能息息相关。这些方面的药物均可以影响青光眼的进展。随着医疗技术的发展以及对青光眼发病机制认识的加深，新型抗青光眼药物也应运而生，为眼科医师提供新的选择。本文将对国内外新型抗青光眼药物从机制、药理特点及临床疗效等方面进行综述。     

Mimengosides J and K: two new neuroprotective triterpenoids from the fruits of Buddleja lindleyana

Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP⁺) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease.

     

接受供精人工授精夫妇生育压力和生活质量研究

目的：调查接受供精人工授精（AID）夫妇的生育压力与生活质量，了解生育压力和生活质量的关系，为这些夫妇进行心理和生活质量干预时提供理论依据。方法：采用患者夫妇一般情况调查表、生育压力量表（FPI量表）和生活质量量表（FertiQoL量表）对北京大学第三医院2018年5—9月生殖中心门诊就诊的129对准备接受AID助孕的夫妇进行横断面调查，比较夫妇双方生育压力和生活质量的差异，分析生育压力和生活质量之间的关系。结果：接受AID的女性患者FPI总分为（159.00±17.52）分，FertiQoL总分为（62.27±9.26）分；男性配偶FPI总得分为（153.91±19.96）分，男性配偶FertiQoL总分为（65.12±11.62）分。女性FPI总分高于男性（t=2.436，P=0.016），女性无子女压力维度得分高于男性（t=3.145，P=0.002）。男性FertiQol总分高于女性（t=-2.881，P=0.005），女性情感反应维度得分高于男性（t=3.681，P=0.000），男性身心关系维度得分高于女性（t=-11.401，P=0.000）。Pearson 相关分析结果显示，接受AID助孕的女性FPI总分及性压力、夫妻关系、父母角色需求压力三个维度与其生活质量呈负相关（P＜0.05），接受AID男性配偶FPI总分和社会压力、性压力、夫妻关系维度、父母角色需求压力这4个维度与其生活质量呈负相关（P＜0.05）。多重线性回归显示，生育压力、居住地、文化程度是影响接受AID助孕女性患者生活质量的重要影响因素（F=3.485，R2=0.168，P＜0.05），生育压力、文化程度、家庭月收入是影响接受AID助孕男性配偶生活质量的重要影响因素（F=4.390，R2=0.203，P＜0.01）。结论：接受AID女性患者生育压力高于男性配偶，生活质量低于男性配偶；生育压力是影响AID夫妇生活质量的重要因素，夫妇双方生育压力越大，生活质量越低。     

In vitro dissolution and oral bioavailability study of fenofibrate nanomatrix system prepared by hot-melt extrusion

Solvent evaporation method for preparation of nanomatrix has the disadvantages, such as residual organic solvent, environmental pollution, explosion-proofing and so on. To overcome these shortcomings, a series of fenofibrate nanomatrix drug delivery system (NDDS) consisting of nano-porous silica Sylysia^®350 (S350) and pH sensitive material Eudragit^® L100-55 (EL100-55) were prepared using hot-melt extrusion (HME), and their in vitro dissolution and in vivo bioavailability were compared. Finally, the formulation with the highest in vivo bioavailability was selected as the optimized formulation for DSC and PXRD characterization. The results showed that the optimized NDDS showed a higher bioavailability than the reference formulation, although there was crystalline form drug remaining in NDDS. The relative bioavailability of the optimized formulation was 157.1% compared with the commercial product Lipanthyl^®. In addition, the relative bioavailability of the optimized formulation was 124.8% in comparison with the formulation prepared by solvent evaporation method, showing that the NDDS prepared by the HME method was effective in improving the bioavailability of fenofibrate. In conclusion, HME was a promising method to prepare NDDS.